None of the patients reported subjective symptoms typical for peripheral neuropathy. Patients were followed for 36 months with repeated neurophysiological examinations on 24 and 36 months after statin treatment initiation. Subsequently, treatment with simvastatin 20 mg daily was initiated. Initial examinations included laboratory and neurophysiological measures (peroneal and tibial nerves: MNCV, CMAP, F-wave mean latency superficial peroneal and sural nerve: SNCV, SNAP). Other metabolic disorders or chronic ethanol abuse were excluded. The frequency of affection of the peripheral nervous system has not been thoroughly investigated our previous study showed the signs of peripheral nerve damage in the results of EMG assessment.įorty-two patients (23 males, 19 females, mean age 51.9 and 52.3 years) with a definitive diagnosis of combined hyperlipidemia were studied. Long-term treatment with statins may have adverse effects: affection of muscles or peripheral nervous system. To confirm the changes in the results of EMG assessment of lower-limb peripheral nerves in patients treated with statins in the longer follow-up period of 3 years.
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